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The diagnostic significance of NT-proBNP in patients with congenital heart disease complicated by pulmonary hypertension

Authors: Tilemanbetova K. T., Tazabekova G. B.
Scientific-Research Institute of Heart Surgery and Organs Transplantation

Objective: To determine diagnostic and prognostic value of NT-proBNP in patients with congenital heart disease complicated by pulmonary hypertension.

Methods: We retrospectively reviewed 60 patients with congenital heart disease complicated by pulmonary hypertension, before and after surgery with confirmation of two-dimensional transthoracic echocardiography.

Results: In this patients following parameters of systolic pulmonary arterial pressure (determined by the Bernouli method) were noted: range 60-120 mm Hg, mean = 90mm Hg. At the same time, there was an increase in NT-pro BNP level indicators from 700 to 5631pg / ml. During the follow up (more than 6 months) after the operating period, a significant decrease in the level of pulmonary arterial pressure is observed in 86% of patients up to 55 mm Hg, and the value of NT-pro BNP from 450-560pg / ml.

Conclusion: These observations allow us to use the method of determining the level of NT-proBNP in patients with congenital heart disease complicated by pulmonary hypertension.